Bioprocess Solutions - Services
ChromaCon offers modular service packages to support the customer’s use of the Contichrom equipment.
Service package 1: Feasibility study (4 weeks)
- Transfer of documents and materials from customer to ChromaCon
- Verification of methods at ChromaCon.
- Verification of preparative batch chromatography step at small scale
- Repetition of the preparative batch chromatographic method but instead of feed material, side-fractions are loaded.
- Estimation of performance improvements (yield, productivity) by the use of MCSGP.
Milestones WP1:
- Verification of preparative batch chromatography step at ChromaCon shows comparable results with respect to yield, purity and chromatograms (preparative and analytical).
- Potential for performance improvements (yield, productivity) by MCSGP modeled.
Service package 2: MCSGP process development (6-8weeks)
- Adaptation of batch chromatographic method in order to make it suitable to design initial MCSGP operating conditions (MCSGP design batch) by variation of column load and gradient shape.
- Design MCSGP operating conditions from MCSGP design batch using ChromaCon’s software tools.
- Run MCSGP experiment with the initial operating conditions to verify model.
Milestones WP2:
- MCSGP experiments provides a yield at least as good as in batch chromatography (at comparable productivities and within product specifications).
- Transfer of work package 2 report (slides) to customer.
Work package 3: MCSGP optimization (6-8 weeks)
- Operate MCSGP at 5 different optimized operating points in order to maximize yield.
- operate the optimal MCSGP experiment for 12-24hrs to prove process stability, collect samples from the four MCSGP outlets, analyze samples, evaluate purities.
Milestones WP3:
- MCSGP experiments give a yield which is significantly better as in batch chromatography (at comparable productivities and with product in specifications).
- Transfer of work package 3 report (slides) and additional documentation to customer.
