Industrial Applications- Synthetic Peptides
The purification of synthetic peptides is challenging, since the impurity profile is complex and overlaps with the desired product. This problem is accentuated for larger peptides, as the more synthesis cycles, the more potential impurities will accumulate and the yield will decrease.
Current preparative purification strategies using conventional HPLC chromatography suffer from low resolution, resulting in low product yield and/or purity as well as high solvent consumption. Re-chromatography of side fractions is used to increase yield but is often tedious and irreproducible, leading to poor process definition.
Benefits of MCSGP:
Examples of purification problems which have proven to be particularly suitable for the MCSGP-process are given below:
- Increase in yield by 50%, retaining target purity
- Reduction of solvent consumption by up to 70%
- Increase in productivity up to 10fold
- Faster process development
- Reduction of operational cost by 50%, CAPEX by 30%
• Large peptides with more than 10 amino acids
• branched and linear peptides
Please refer to our case studies in the " download section " for more information.
